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Antibodies, part 1, Anti-TPO

This is part 1 in a series on anti bodies and auto immune thyreoditis. In this first part I will take a look at anti bodies in general and Anti-TPO in particular. I think you will be a little surprised at some of the findings. It’s maybe a little nerdy for some. But the main points are listed in the summary. 

This is a complex topic, and there is a lot of research going on. I will probably revise these posts as I learn more. 

Abstract

All anti bodies look the same, Y shaped. They differ only on the tips of the Y. That is where they bind onto specific anti genes. People without thyroid disease can also have low levels of anti bodies, particularly Anti-TPO and Anti-TG. But whether they GET a thyroid disease later, we don’t know. A study showed, that many women had anti bodies up to 7 years before they got symptoms (1).

All antibodies are produced within the thyroid itself by B lymphocytes. So if on has little or no thyroid, one does not have high levels of anti bodies.

TPO is an enzyme that takes part in the process where Iodide gets converted into Iodine. Iodine is the form the thyroid uses in it’s hormone production. TPO can get damaged by oxidative stress. Anti-TPO then gets produced against the damaged enzyme. Oxidative stress can  start as a result of Iodine deficiency. The process has started. 

Anti-TPO is not what causes the greatest damage to the thyroid. It’s B and T lymphocytes that do that. Plus a form of the TRAb anti body, the cleavage TRAb. That can cause cell death as well. I will write about that in part 3.

One can have high levels of Anti-TPO without the thyroid decreasing in size. We call everything Hashimotos, but that is not correct. Hashimotos is the AIDT that starts with a goiter. The thyroid gets infiltrated by B and T lymphocytes, and cannot function as it should. But it doesn’t atrophy. Whereas Ord’s does not start with a goiter, and the thyroid atrophies. I will write more about that in a later part in the series.

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Mother Meera

Some people will think, what has this post to do with thyroid issues? It has a lot to do with it. The body is only for a little while, the soul is for ever. And how we feel impacts our bodies in a major way.

Also, AIDT has to do with trauma in many people. I am not saying all. I will get back to this in a future post.

But anyway, I write on my home page, I will share things that have helped or help me. Mother Meera has helped me A LOT. She has helped heal some deep wounds in me. I had a dream many years ago, in the beginning when I first started visiting her in Germany. 

I dreamt I was in an enormous crater that had been dug out. Big enough for a sky scraper. There were these huge construction vehicles. In the middle, in a car on top of a mound sat Mother Meera giving me darshan through the window. That says something about the scope of my process. 

I am writing this now, in February 2021. I am thinking maybe you are a little down, maybe you feel lonely. Maybe you have had a hard time in these Covid times?  I was thinking, maybe you need some comfort. Maybe Mother can help you as she as helped me.

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WELCOME

Trykk på “Meny” for norsk

Welcome to my blog on everything thyroid. I want to write about things I think can help us feel good. Yes, we can feel good even though we are not totally well. But it takes becoming optimal on our thyroid levels and on the medicine that is best for us. Everybody doesn’t have this option. I will do what I can to change this. I will give my take on things like optimal levels, reverse T3, NDT and much more. As well as present studies, and maybe make them easier to understand for those not so familiar with scientific publications. I will also write on other things to do with our health and well being. We are so much more than our thyroid disease. We need to be in good shape on many other parameters, not just our thyroid levels.

The blog is meant for inspiration. I hope you find something of interest, something that you together with your doctor can implement. And hopefully, feel better.  

CONVERSION, DEODINASE

I have translated some of Thyroid Patients Canada’ articles on conversion into Norwegian. These articles are very interesting, esp this one, https://thyroidpatients.ca/2019/11/12/the-basics-of-thyroid-hormone-action-transport-and-conversion/      

Most of the hormone conversion, T4 to T3 happens outside the thyroid. though there are big individual differences how much.  There are 3 enzymes responsible for this conversion, D1, D2 and D3. They do a lot more than convert T4 to T3 though.

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FT3 UPS AND DOWNS IN T3 THERAPY

This is not really a post. I have translated Tania Sona Smith’s article, https://thyroidpatients.ca/2019/11/25/free-t3-peaks-and-valleys-in-t3-and-ndt-therapy/ , into Norwegian.  For every Norwegian page, I want there to be a corresponding English, and vice versa.  

This is just a presentation of Tania’s piece. She is looking into the reseach on how Ft3 behaves after dosing with T3 containing medicine.  Actually, there is not really any good studies on the subject . There is a study on FT3 after a single dose of T3. But that is not what most people take when dosing with T3. We do multidoses. There is no study on FT3 when multidosing, but there is one on T3, that is total T3. Where I live in Denmark, we cannot have FT3 tested. The endoes have forbidden it, they claim, FT3 fluctuates too much, it cannot be trusted. How do they know? With no studies? Anyway, FT3 and T3 follow each other in most instances . With a very important exception, when we take estrogen orally. Then both T4 and T3 becomes higher and FT4 and FT3 lower. So  VERY important to have the frees tested.

Anyway, there is a study on multidosing and T3, showing that T3 peaks app 2 hours after intake. So pretty unstable. Except of course, the peaking is very easy to predict. At least for us patients. I don’t know if the Danish endos,( and the English) have heard about the single dose experiment (Jonklaas et al, 2015) maybe, where one sees a huge peak after intake of 50 mcg T3 in one go. If that is the fluctuation that has scared the shit out of them. And then they never got around to reading  Busnardo et al’s study(1980) on total T3 and multidosing. Even though that study has been around for 40 years. 

Tania goes into all this and more.  We really need a good study on the FT3 level through the day and night. Preferably for all three T3 containing meds, Mono T3, synthethic T4/T3 and NDT.  And with differing dosingregimes. We are many today who also take a dose of T3 at bedtime, others set the alarm 2 hours before getting up, to provide T3 for the cortisolproduction that takes place in the early morning.  Considering how FT3 probably peaks 2 hours afterdose, that is maybe not the best time to take it. Anyway, such a study would be great.

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