This is an info file Brian Haviland has written. He is the admin in the Face book group, LDN, Low dose Naltroxene for chronic illness and infections, https://www.facebook.com/groups/108424385861883/about/ . Brian is not a doctor, but he is one of those people who know a lot about LDN. LDN is a patient driven medication, we are the ones who propel the field forwards. As doctors didn’t take much interest earlier. Now many seem to come round, and realize, LDN is a very powerful medicine.
Tramadol is a centrally acting synthetic opioid analgesic and SNRI
(serotonin/norepinephrine reuptake-inhibitor) that is structurally related to codeine and morphine.” https://www.drugbank.ca/drugs/DB00193
Many LDN users who need pain relief take Tramadol without a problem. It is different from normal opiates because it binds more weakly to the mu receptor. In fact a lot of the pain relief comes from its action as an anti-depressant. It is a SNRI. The pain killing strength can be enhanced by taking it with Tylenol as the two are synergistic with each other. The two drugs combined are marketed as Ultracet. There was also a comment from a user that adding the Tylenol helps with nausea that the Tramadol would otherwise cause for her.
Note though that it is a different situation if someone has been taking regular doses of Tramadol for some time before wanting to start LDN. A person in this situation is more likely to have some withdrawal type issues and should learn about using the lower dose ULDN as a way to get started. Ask for more info.
Some doctors/pharmacists recommend taking it 4-6 hours away from LDN but this is not universal — our Dr. Skip says it is not necessary, but he says LDN users should not go above 300mg/day or use the sustained release version. At one point I took it for several months and did not notice any difference when taken at the same time.
Regardless of the timing issues anyone taking Tramadol should learn as much as they can about it. It is habit forming and can produce serious withdrawal symptoms. When getting off of it do it VERY slowly (talking weeks/months of gradual reduction). I am not a doctor — just speaking from my own experience and what I’ve read. This is an excellent site for more info….
https://medlineplus.gov/druginfo/meds/a695011.html Before taking Tramadol review a list of all your medications and supplements with your pharmacist to avoid potentially dangerous interactions.
The Mechanism for Tramadol (Ultram) Induced Risk of Serotonin Syndrome in Patients Taking SSRI Antidepressants, https://www.ebmconsult.com/articles/tramadol-interaction-ssri-serotonin-syndrome-mechanism
Tramadol – Seizures, Serotonin Syndrome, and Coadministered Antidepressants, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714818/
Clinical pharmacology of tramadol, https://pubmed.ncbi.nlm.nih.gov/15509185/
Some concerns about Tylenol (“acetaminophen” or “paracetamol,”) and a suggestion to take NAC if using it, https://suzycohen.com/articles/acetaminophen_liver_side_effects/
Tramadol Detox – Withdrawal and Tapering Guidelines, https://www.choosehelp.com/topics/detox/ultram-detox-tramadol-withdrawal-pains.html
Widely Prescribed Opioid Drug Linked To Higher Hypoglycemia Risk, http://www.pharmaciststeve.com/?p=31425
Tramadol Use Shown to Increase Hip Fracture Risk in Older Adults, https://www.hcplive.com/view/tramadol-use-increase-hip-fracture-risk?&fbclid=IwAR2nu-QUYtGgjjz1GmnSd2Q0Exf82Ca6xoFkHHiQfOEf7VaqzkR_fN7FqN0