WELCOME

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Welcome to my blog on everything thyroid. I want to write about things I think can help us feel good. Yes, we can feel good even though we are not totally well. But it takes becoming optimal on our thyroid levels and on the medicine that is best for us. Everybody doesn’t have this option. I will do what I can to change this. I will give my take on things like optimal levels, reverse T3, NDT and much more. As well as present studies, and maybe make them easier to understand for those not so familiar with scientific publications. I will also write on other things to do with our health and well being. We are so much more than our thyroid disease. We need to be in good shape on many other parameters, not just our thyroid levels.

The blog is meant for inspiration. I hope you find something of interest, something that you together with your doctor can implement. And hopefully, feel better.  

Antibodies, part 2, Anti-thyroglobulin

Thyroid patients are very focused on anti-TPO, but anti-TG is also important. If we have high levels, it can mean, that there is some damage to our thyroid. And did you know that 10% of Hashimotos patients don’t even have anti-TPO, only anti-TG?

Abstact

Thyroglobulin is a large molecule. It’s involved in the manufacturing and storage of thyroid hormones. It’s supposed to stay primarily INSIDE the thyroid. But it’s normal to have tiny amounts floating around in the circul-ation. We can get anti bodies to the thyro-globulin when levels become high, anti-TG.  

Thyroglobulin can release into the circulation in various ways: 

When the thyroid is being destroyed.

When the thyroglobulin contains very little iodine.

When they suddenly contain much more iodine (when one has been iodine deficient and suddenly increase iodine intake by a lot). 

And lastly, in thyroid cancer, TG can get released in connection with the synthetization of hormone. 

We don’t know for sure whether high anti-TG levels are bad for us. But it does play a role in the auto immunity of AITD.

It’s important to test  anti-TG when one suspects AITD, because 10% have only elevated levels of anti-TG, and not anti-TPO. I don’t think many doctors are aware of that fact. 

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Iodine for beginners

This is a post for you who maybe know, or suspect, you suffer from iodine deficiency. But at the same time, you may be scared of supplementing with iodine. In this post, I won’t be referring to heaps of studies, as I want to keep it easy and assessible.  But everything I write, I have read in books or studies. Except when I write “I believe” or “I think”.

Iodine deficiency

A lot of people suffer from iodine deficiency. And even more so us with thyroid disorders. Iodine deficiency is the number one reason for thyroid disorders. I am not saying it’s the only reason. You might not suffer from a thyroid disorder though. There is an almost phobia of iodine in the world, you can read more about that here

At the same time as we often get too little iodine, we have big issues with other halogens occupying the iodine receptors. Iodine is a halogen, and toxins like Fluoride, Bromide and Chloride can occupy the iodine receptors. This happens less if we have ample iodine in our bodies.

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Antibodies, part 1, Anti-TPO

This is part 1 in a series on anti bodies and auto immune thyreoditis. In this first part I will take a look at anti bodies in general and Anti-TPO in particular. I think you will be a little surprised at some of the findings. It’s maybe a little nerdy for some. But the main points are listed in the summary. 

This is a complex topic, and there is a lot of research going on. I will probably revise these posts as I learn more. 

Abstract

All anti bodies look the same, Y shaped. They differ only on the tips of the Y. That is where they bind onto specific anti genes. People without thyroid disease can also have low levels of anti bodies, particularly Anti-TPO and Anti-TG. But whether they GET a thyroid disease later, we don’t know. A study showed, that many women had anti bodies up to 7 years before they got symptoms (1).

All antibodies are produced within the thyroid itself by B lymphocytes. So if on has little or no thyroid, one does not have high levels of anti bodies.

TPO is an enzyme that takes part in the process where Iodide gets converted into Iodine. Iodine is the form the thyroid uses in it’s hormone production. TPO can get damaged by oxidative stress. Anti-TPO then gets produced against the damaged enzyme. Oxidative stress can  start as a result of Iodine deficiency. The process has started. 

Anti-TPO is not what causes the greatest damage to the thyroid. It’s B and T lymphocytes that do that. Plus a form of the TRAb anti body, the cleavage TRAb. That can cause cell death as well. I will write about that in part 3.

One can have high levels of Anti-TPO without the thyroid decreasing in size. We call everything Hashimotos, but that is not correct. Hashimotos is the AIDT that starts with a goiter. The thyroid gets infiltrated by B and T lymphocytes, and cannot function as it should. But it doesn’t atrophy. Whereas Ord’s does not start with a goiter, and the thyroid atrophies. I will write more about that in a later part in the series.

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Mother Meera

Some people will think, what has this post to do with thyroid issues? It has a lot to do with it. The body is only for a little while, the soul is for ever. And how we feel impacts our bodies in a major way.

Also, AIDT has to do with trauma in many people. I am not saying all. I will get back to this in a future post.

But anyway, I write on my home page, I will share things that have helped or help me. Mother Meera has helped me A LOT. She has helped heal some deep wounds in me. I had a dream many years ago, in the beginning when I first started visiting her in Germany. 

I dreamt I was in an enormous crater that had been dug out. Big enough for a sky scraper. There were these huge construction vehicles. In the middle, in a car on top of a mound sat Mother Meera giving me darshan through the window. That says something about the scope of my process. 

I am writing this now, in February 2021. I am thinking maybe you are a little down, maybe you feel lonely. Maybe you have had a hard time in these Covid times?  I was thinking, maybe you need some comfort. Maybe Mother can help you as she as helped me.

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Living with disease

Living life and feeling good despite having a chronic disease, I am sure everybody is working on that. Still, i would like to share how I have gotten to where I am today.

Where am I today? In Paradise? Not quite, ha ha. But I am sure I could be. But I feel very much better than some years back, physically and mentally.  These two are connected of course. But the mental is maybe the most important. It’s very difficult to feel good if you have a way too low FT3. But you can feel good even if your health isn’t 100%. And you can feel bad even if your health is 100%.

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Male hormones

Abstract

Whilst not being an expert on testosterone treatment for men. I have read a bunch of studies in order to write this post. I have a post on female hormones, and then I must have one about you men as well. Of course This is not meant to be a comprehencive overview of all things testosterone. More as a wake up call to you men with thyroid issues. Low T is a common and natural result of having low or high thyroid levels. Nothing to be embarrassed about!  In North-America, I believe there is a lot of focus on sex hormone levels. So for you living there, this post might be of little interest. But in  many countries, it’s not like that.

There is a strong connection between thyroid and testosterone levels. For both high and low thyroid levels. It does normalize in most men after thyroid levels are again normal. But not for everybody. An then you have the age related 1 to 2% decrease after age 30.

We thyroid sick already have less energy. Which will lead to lower libido. Even when our thyroid levels are optimal, we are often not as energetic as we were before getting sick.  So for us, it’s extra important to be optimal on all parameters. 

What are the symptoms of Low T?

There are of course things one needs to be aware of before starting on T therapy. As far as I can see from the various studies I have looked at, they no longer think there is an increased risk of cancer in the prostate. There are conflicting findings on cardiovascular health, both negative and positive effects. If one is predisposed, or already suffer from one of these conditions, it’s another matter of course.

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HOW IS NDT MADE?

I have got to admit, I have been very ignorant about how NDT is made. I have believed that NDT and glandular supplements, like Metavive and Thyrogold, were virtually the same.  And I have been telling people that. They are not, glandular is a much weaker product. I could be embarrassed about this. But I choose not to.  This only proves my point, that there is so much to learn about this thyroid issue. Let’s try to stay openminded, and just admit when we are mistaken. That is the only way to learn something new.

I have this info from Chris at Pim Pom products, also the photos.  Most of it is a direct quote from him.  I have just added a little. Thanks, Chris!

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Quality of NDT

There is so much talk of issues with NDT. And I have already written one post about it. I hope to be a sobering voice. I see a lot of stress and worry created, especially in the US. We take it more easy here in Europe. 

Is there any need for worry? No, you don’t need to worry. Only people who do not know anything about their optimal levels, or how to monitor them, need to worry. You will learn how to do these things, if you don’t already know it. I will teach you.  Follow your temperature and pulse, guide below. Then you just adjust your dose as needed. 

Because thyroid meds will continue to fluctuate also in  the future. And not only NDT, synthetic meds differ in their hormone levels as well. There is just now, August 2021, a new study on Levothyroxine. Where the authors think the medicine is so inconsistent, it should be put to bed. You can read more about that  here.  

USP standard for NDT

Synthetic T4 meds like Synthroid and Levo, are legally allowed to vary between 95 and 105 % of the given amount.  So your current batch can be 10 % stronger or weaker than your previous batch. NDT and synthetic T3 medicine is allowed to vary between 90 and 110 %, US pharmacopia.

Recall of NT and WP 2020 and NP Acella nov 2020

The recall of Nature Throid and Westhroid in 2020 was NDT that might contain 87 % of the given amount. That is 3 % less than what is allowed. OMG! In hormone content, that would be hardly anything. The same with the NP recall in November 2020. That was also a sub potency at 87%. 

The FDA asked RCL labs to recall 6 lots . They tested 10 lots and found 6 to be subpotent, and writes that “some may be subpotent at 87%”, link to FDA recall . And criticized RCL for lack of procedures. 

 But RCL labs recalled all 483 lots from all over the world. I said at the time, now Nature Throid will no longer be an affordable option. And we see now, that I was unfortunately right.  It’s us patients who will pay the price of course. That was a very bad judgement call on behalf of RCL labs. I am thinking, with all the negativity going around in the US, originating from the STTM, they are maybe nervous. Why not just go out and say, all of these lots may be a little sub potent, please check your levels and adjust dose? There is a real shortage of NDT raw material in the world, due to the African swine fever. Can we afford to destroy large amounts of NDT? The NDT  certainly becomes more and more expensive as a result.

NP Acella recall summer 2020

 

And last summer (2020), NP Acella recalled product due to what they called “super potency”, it could contain 115 % T3 of given amount. That is 5 % over the allowed amount. Super potent? It would make for 1 to 1,5 mcg more T3 pr 60 mg, which normally contains 9 mcg T3. Most people would hardly notice such an increase. NP Acella warns, this could be dangerous to pregnant women. BS, is all I can say. 

It becomes a big drama. I know people who took NT from the recalled lots. They noticed no difference. 

This is the world we live in, all thyroid meds vary in hormone content. I am not saying this is good, and that we should just accept it. But I don’t know how easy it is to rectify it. Not even for the synthetic meds. If you have a look at the study on Levo that I link to over, you see, that the authors highlight detoriation that takes place in Levo that the FDA tests cannot detect. And that make it inconsistent, and even reactive. Maybe this is why so many of us have serious side effects on Levo?

And I believe, making and testing NDT is even more difficult. And keep in mind, each liquid chromatography can cost 3000 US dollars. WE will be the ones paying for increased testing. You can read more about how NDT is made and tested here

But, of course, the manufactures must have quality procedures in place. No doubt about that. Both RCL labs and Acella need to do better. Both synthetic and organic thyroid meds need to be more consistent.

Do all pigs have the same thyroid levels?

No they don’t. They are like us humans. Their levels vary with age, gender and even breed. I don’t know how this reflects in the actual NDT powder. But we do know the different NDT brands vary in hormone content. 

These graphs are from this study by Petkov

Table 1. Age- and gender-related variations in blood thyroid hormones in HCS Shoumen

Shoumen is a big pig company in Bulgaria. There are even variations between breeds:

Table 2. Breed- and gender related variations in blood thyroid hormones in Duroc (DD), Landrace (DL) and Yourshire (DY) pigs; HCS Shoumen.

What are the consequenses of these recalls?

The consequences are very serious. Patients are becoming scared and worried. This fear goes directly to our adrenals, which are often weak already. Sites like STTM and their corresponding FB groups also stirs up a lot of anger and conspiration theories. Which creates even more turmoil in many people. I don’t think most patients go very deep into this themselves, really look at the numbers and think.  I hope my post will make you do that.

Our NDT will become more expencive. When so much product goes to waste, there is only one person who will pay for that, YOU. 

Patients will have to change meds, which is very scary to many. Last year, Nature Throid was not to be had.  It can become expencive to change meds. It could entail a visit to the doctor, having to apply for a new license, having to buy a  more expensive brand. Maybe even being without NDT for a period. Or maybe even switching back to synthetic for good, and doing less well.

STTM rages against the NDT producers. I am becoming more and more pissed at the FDA. I find it very irresponsible what they are doing. I see in US groups, people talking about Big Pharma in this situation. Don’t you see, you are palying into the hands of Big Pharma? NDT producers are not Big Pharma, synthetic T4 producers are Big Pharma. 

FDA, I hope you are scrutinizing synthetic thyroid meds as well. I suspect not.

What can WE do?

We can monitor our levels when starting on a new batch. If you follow your pulse and temperature, you will know when to adjust dose. And keep in mind, there are many other reasons for our levels fluctuating besides variations in our meds. 

 

How to take the temperature

Measure before getting up and again in the afternoon. Preferably with a glass thermometer. Measure rectally or vaginally. Should be 98,6 F or 37 C in the afternoon, a little lower in the morning. 


How to take the pulse

Pulse is more individual than temp. What I have done, it taking my pulse when my temp is 37 C and I feel good, and go by that. For me that is a pulse around 72 in the morning and 80 in the afternoon. A very low pulse is never good.

 

Let us take things down a notch. If it is possible to raise the quality of our NDT, I hope it will be done. But if it is difficult to avoid variations, talk to us, inform us, work with us. We all want the same thing, good and consistent  NDT 

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Important new study on Levothyroxine. Chemical processes in the tablet make for inconsistent hormone content. Maybe even side effects?

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