Calorie restricted diet
The decrease in thyroid hormones that one sees with fasting and dieting, is connected to the fact that the body goes in saving modus plus less Leptin. One sees FT3 decreasing, while FT4 goes up temporarily. During the first 2 weeks, RT3 increases. But normalizes again after that time. The normalization of RT3 is because FT3 is now lowered. The increase in RT3 is caused by less deiodinase, not increased conversion of T4 to RT3. This statement is a mystery to me. How is RT3 made except from conversion of T4 to RT3? The fall in T3 is caused by less conversion of T4 to T3. Less ATP (small monecules transporting energy to the parts of the cells that need it) can give less uptake of T4 in the liver, plus less deiodinase in tissues.
Leptin plays a crucial role. Leptin levels fall in concordance with the weight loss. If one takes Leptin one does not see the low thyroid hormone levels.
I don’t know that much about Leptin, but will be studying it. And write about it. But what is important, is that RT3 increases only the first 2 weeks. After that it is low FT3 that is the problem. I think we can conclude, low calorie diets are not the best for us hypothyroid.
When having HIV, one also gets a form of NIT. FT3 becomes low. But there is no increase in RT3. Thyroglobulin increases as well as the disease progresses. They can also acquire an actual hypo thyroidisme as pathogens infiltrate the thyroid. Much like Hashimotos thyroiditis.
Our thyroid levels are of utmost importance for our heart’s functioning. They govern the heart’s rhythm, minute volume, systemic vascular resistance and how much the heart contracts (inotropism). When having a heart attack, T4, T3 and TSH falls, and RT3 increases.
The kidneys play a crucial role in our thyroid hormone conversion and excretion. App 20% of our thyroid hormone conversion takes place here. With individual variations. So no wonderm that people with renal disease get low thyroid hormone levels. One does not see increased RT3 levles, but lower FT3 and thyroglobulin can also become lower.
The liver is the main organ when it comes to conversion T4 to T3, synthesizing of thyroglobulin, uptake of T4 and second most important when it comes to excretion of T4 and T3 into the blood stream. I would think it was the organ releasing the most T3, but this is what it says. One often sees thyroid levels affected with cirrhosis of the liver, Hepatitis and chronic liver disease.
Seeing as the liver is so important for our thyroid levels, it’s a good idea to take good care of it. The most beneficial for the liver, is giving it a rest. If you don’t eat any fat for 2, 3, 4 weeks, eating only greens and fruits, it starting cleansing itself.
Many herbs are also helpful. I have taken heaps of Milk thistle and Artichoke. And many recommend them for us thyroid sick.But, turns out, they are not so good for us. I fell over this study, link to study on Milk thistle. We have 3 main thyroid hormone transporters. Our thyroid hormones cannot get into our cells except through those. MCT8 is one of those transporters. Silymarin (active ingredient in those herbs )inhibits T3 uptake by this transporter. Other studies show that Silymarin is good for other aspects of thyroid function. But all in all, probably better to use some other herbs.
Bitter compounds are very important for our liver and gall function. In China and India they are well aware of this, and include something bitter in all meals. It’s only here in the West we don’t understand this. Maybe except France. But we knew it in earlier times. Bitters were much used to aid digestion.
What can we use instead of Silymarin containing herbs? Dandelion is good, as well as Turmeric. Coffee enemas can also be helpful. Dr Hulda Clarks gall bladder flush is very harsh. I have done it 4 times. Never again.
Diabetics often have abnormalities in their thyroid levels. Some studies have shown decreased TT3, Total T3, levels, and in some cases also decreased TT4. One sees also increased Reverse T3. I see some thyroid sites claim that this is because of badly regulated glucose levels. One has also found that it can have to do with inflammation, something called proinflammatory markers, like IL-6. This is beyond the scope of this article, but it is interesting.