Reverse T3 is not the big bad wolf in our thyroid system. It is a necessary brake where FT3 is the gas pedal. We can get too much RT3 when we take more T4 medicine than we are able to convert to T3. Could be just too high dose, or that we don’t convert well. Other conditions can increase RT3 too much as well. It’s a good idea to test RT3 from time to time. But it is not necessary to test all the time.
I will look at myths and misunderstandings around RT3. for one thing, RT3 does not block T3 by occupying T3 receptors. Nor does it hinder T4 to T3 conversion. If there is a big bad wolf, it’s deiodinase 3, D3. It’s D3 who converts T4 to RT3, and who hinders T3 from attaching to the T3 receptors i the cell nucleus.
But there are no “wolves” in our thyroid system. Only participants with their own roles to play. And the better we understand the play, the more can we hopefully optimize our thyroid levels and feel better.
I will look at what causes too high RT3, and what one can do bring it down.
As with LDN, I am no expert on Iodine. I am on it myself, have been for about 6 minths here in may 2020. I will be updating the post as I go along. I will be absolutly honest about what is happening. I won’t be writing too much about the complicated aspects of Iodine. But I want to present some of it. So if you are mostly interested in the more practical aspects and concrete tips, scroll down to “The Protocol”.
THE WOLFF/CHAIKOFF EFFECT
Since I began reading about Iodine, I have realized most of us lack Iodine. In 2007, I was a patient at a national center for thyroid disease in Oslo, Norway. Chief Physician Ingrid Norheim told me, avoid all kinds of Iodine. Don’t take a multivitamin containing Iodine. I listened and believed her. She suffered from the Iodine fear that has plagued the world the past 70 years. Ever since Wolff and Chaikoff’s study from 1948, link to the Wolff / Chaikoff study. The study says that big doses of iodine that exceeds a certain level in the blood, 0,2 mg/L, will hinder inorganic iodine from organification inside the thyroid, that is, there will be less thyroidhormone produced. So one will become hypothyroid. G.E. Abraham, the nestor in the Iodine field, says these rats that were given large doses of Iodine, didn’t become hypothyroid. And their thyroid levels weren’t even measured, not before or after the Iodine was injected, link to G.E. Abrahams article.
NO, NDT hasn’t gone bad. That is the short answer. I take NDT myself, and it works just fine.
I see people claiming, NDT is no good anymore. That it is better to take synthetic T4/T3 now. I think this is very serious, that this incorrect, untrue info is being spread in the Facebook groups. It stems from STTM, Stop the Thyroid Madness, and its Facebook group, Adrenal Fatigue and Thyroid Care. STTM is a site that has contributed so much, and I am sad to see, there is such black and white thinking going on. This issue isn’t black and white.
How do I convert my T4 dose to NDT?
This is a question one sees often in the thyroid Facebook groups. There is a lot of confusion and insecurity around this. Which is not so strange, as there is very little good info on the topic. The conversion tables the NDT (thyroid) producers themselves provide are ridiculously low. They are wrong, wrong, wrong. I don’t understand how they think at all. If they do. Think. One would be seriously under dosed if adhering to those guidelines. And if one’s doctor reads them, one could get serious problems. I don’t know how many doctors read these instructions. I hope they don’t. Here is a table from Nature Troid as a (bad) example.
I have translated some of Thyroid Patients Canada’ articles on conversion into Norwegian. These articles are very interesting, esp this one, https://thyroidpatients.ca/2019/11/12/the-basics-of-thyroid-hormone-action-transport-and-conversion/
Most of the hormone conversion, T4 to T3 happens outside the thyroid. though there are big individual differences how much. There are 3 enzymes responsible for this conversion, D1, D2 and D3. They do a lot more than convert T4 to T3 though.
This is not really a post. I have translated Tania Sona Smith’s article, https://thyroidpatients.ca/2019/11/25/free-t3-peaks-and-valleys-in-t3-and-ndt-therapy/ , into Norwegian. For every Norwegian page, I want there to be a corresponding English, and vice versa.
This is just a presentation of Tania’s piece. She is looking into the reseach on how Ft3 behaves after dosing with T3 containing medicine. Actually, there is not really any good studies on the subject . There is a study on FT3 after a single dose of T3. But that is not what most people take when dosing with T3. We do multidoses. There is no study on FT3 when multidosing, but there is one on T3, that is total T3. Where I live in Denmark, we cannot have FT3 tested. The endoes have forbidden it, they claim, FT3 fluctuates too much, it cannot be trusted. How do they know? With no studies? Anyway, FT3 and T3 follow each other in most instances . With a very important exception, when we take estrogen orally. Then both T4 and T3 becomes higher and FT4 and FT3 lower. So VERY important to have the frees tested.
This is just a short abstract of Thyroid Patients Canada’s article on Triac, https://thyroidpatients.ca/2020/01/02/when-dosing-t3-you-get-higher-levels-of-triac/ . I just want to draw your attention to this metabolite. The quistionmark on the image, is meant to signify my surprice when learning of Triac. I had never heard of this thyroidhormone metabolite until I read Tania’s post. It is quite strange, as it has been studied since the 1950ies. I don’t think many of our doctors have ever heard of it.
So what is it? It is a thyroidhormone metabolite like FT4 and FT3 are. It acts much as FT3, it’s abbreveration is TA3. It has a much shorter halflife than FT3, about 6 times faster.